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ea0044oc4.5 | Adrenal and Steroids | SFEBES2016

ARID1a is required for regulation of a subset of glucocorticoid target genes involved in cell-cycle and p53 pathway regulation

Stubbs Felicity E. , Birnie Matthew T. , Fang Hai , Biddie Simon C. , Lightman Stafford L. , Conway-Campbell Becky L.

Clinically, glucocorticoids are widely used as a treatment mainly due to their potent anti-inflammatory abilities, however these are associated with several side effects and furthermore some patients go on to develop glucocorticoid resistance. ARID1a mutations have been linked to glucocorticoid resistance and are frequently identified across numerous cancers; therefore it is important to determine the functional role of ARID1a to GR signalling. The ATPase driven SWItch/Sucrose...

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ea0044oc4.3 | Adrenal and Steroids | SFEBES2016

Genome wide ChIP-Seq analysis of Glucocorticoid Receptor and RNA Polymerase 2 binding in rat liver during physiological and non-physiological corticosterone replacement

Flynn Benjamin P. , Birnie Matthew T. , Kershaw Yvonne M. , Baek Songjoon , Kim Sohyoung , Stavreva Diana A. , Hager Gordon L. , Lightman Stafford L. , Conway-Campbell Becky L.

Ultradian glucocorticoid (GC) secretion is highly conserved, having been detected in all species studied. The GC corticosterone (CORT) is a ligand for the glucocorticoid receptor (GR), inducing GR recruitment to glucocorticoid responsive elements (GREs) to modulate transcription of GC-target genes. We have previously demonstrated that pulsatile GR recruitment to GREs upstream of the Period1 gene is associated with its pulsatile transcription in rat liver. Similarly th...

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Endocrine Abstracts

ARID1a is required for regulation of a subset of glucocorticoid target genes involved in cell-cycle and p53 pathway regulation

Genome wide ChIP-Seq analysis of Glucocorticoid Receptor and RNA Polymerase 2 binding in rat liver during physiological and non-physiological corticosterone replacement

BiosciAbstracts